HIGHLIGHTING CARDIOVASCULAR RESEARCH AT UNIVERSITY OF CHICAGO

Wednesday, May 7, 2025

GCIS Atrium

Appetizers and beverages served.

4:30-6:30 PM

POSTER SESSION

abstracts have been archived as of 5/8/2025

Mary Acosta:

1-Sodium Glucose CoTransporter-2 Inhibitor following Left Ventricular Assist Device Implantation: a Randomized Controlled Trial
2-Short-Term Outcomes Comparable in Immediate vs Delayed Kidney Transplantation After Heart Transplantation

Bartu Altiparmak:

3-Electrical Properties and Regulatory Mechanisms of Arrhythmic Substrate in Aging

Shalise Burch:

4-Birth defect causation in Down Syndrome: Diminished response to Hedgehog signaling in Trisomy 21 cardiac progenitors

Ozanna Burnicka-Turek:

5-Increased Tbx5 Expression Disrupts Atrial Electrophysiology and Gene Networks, Enhancing Susceptibility to Atrial Fibrillation

Lourdes Caceres:

6-Therapeutic potential of caloric restriction-induced macrophages (CR-Mø) for atherosclerosis resolution

Robin Canac:

7-A Hedgehog Signaling Progenitor Delay Model for Establishment of the Distinct Cardiac Progenitor Fields

Kathleen Cao:

8-Shape Variability of Ascending Aortas during the Cardiac Cycle

Tommy Chiou:

9-Clinical Utility of Cardiac Magnetic Resonance in Transthyretin Cardiac Amyloidosis Risk Prediction

Charles Davis:

10-Is “Stable” A Successful Outcome for Thoracic Aortic Aneurysms?

Sanjeev Dhara:

11-Computational Fluid Dynamic Analysis of Endoleak Flows

Anna Gaffney:

12-Spontaneous conical structures and stress localization in surgically motivated computational models

Martin Gruca:

13-Noninvasive Assessment of Left Ventricular Performance Using Pressure-Volume Loops Derived from Three-Dimensional Echocardiography

Brittany Hazzard:

14-Baboon GTEx Project

Hsin-Chiao Huang:

15-Comparative genomics between human and chimpanzees –using cardiovascular cell types as an example

Amber Johnson:

16-Involving End-Users in Co-Designing mHealth Interventions for Hypertension Self-management

Shreeya Joshee:

17-Electroanatomic Mapping to Identify Viable Transvenous Atrial Pacing Site in Post-Fontan Patient with an Extra-Cardiac Baffle

Ana Lanier:

18-Alternative Measures of Body Composition and Outcomes Following Heart Transplant

Sonja Lazarevic:

19-An altered atrial TBX5-dependent gene regulatory network links heart failure and atrial fibrillation

Aleksei Mikhailov:

20-Differential Temporal Dynamics of Parasympathetic and Sympathetic Cardiac Nerve Activity and Electrogram Patterns in a Chronic Atrial Fibrillation Canine Model

Wiktor Mikolajczak:

21-Hedgehog signaling controls the differentiation timing of the cardiac progenitor fields

Deqa Muse:

22-Establishing a baseline of aortic shape and left ventricular myocardial volume in healthy patients

Ann Nguyen:

23-Reduced Density of Commensal Gut Microbial Species is associated with Post Heart Transplant Infection

Joanna Obaoye:

24-Advanced Right-Sided Hemodynamic Parameters for Prognostication in Patients with Cardiogenic Shock
25-Left-Sided and Right-Sided Composite Advanced Hemodynamic Metrics for Prognostication in Heart Failure
26-The Sound of Local Gunfire is Associated with a Temporal Rise in Blood Pressure in Chicago

Cian O’Donnell:

27-Region-Specific Frequency Dependent Upregulation of Senescence Markers in the Left Atrium in a Chronic Atrial Fibrillation Canine Model

Mathew Padanilam:

28-Left Bundle Branch Block with Time to Notch in Lead I is a Predictor of Response to Cardiac Resynchronization Therapy: A Sub-Analysis of the REVERSE Study
29-Catheter Ablation for Ventricular Arrhythmias Reduces Rehospitalization: An Analysis of a Large Claims Database

Joseph Pugar:

30-Predictive Modeling of Aortic Morphology Post-Intervention Using Sparse Identification of Nonlinear Dynamics (SINDy)

Michael Randazzo:

31-Independent External Validation of Deep Learning-based Echocardiographic Detection of Cardiac Amyloidosis using a Global Multiethnic Population
32-Echocardiographic Phenotypes of Severe Pulmonary Arterial Hypertension Defined by Unsupervised Machine Learning Informs Prognosis
33-Development of a Novel Multiparametric Echocardiographic Score for the Detection of Cardiac Amyloidosis and Validation Compared to Current Methods

Ryan Sachar:

34-Advanced Hemodynamic Metrics in the Assessment of Heart Failure with Preserved Ejection Fraction

Neal Shah:

35-LA Strain and LA Strain Index Predict MACE
36-Non-invasive Assessment of Right Ventricular to Pulmonary Arterial Coupling in Decompensated Heart Failure and its Prognostic Implications

Isaak Tarampoulous:

37-Hedgehog signaling antagonizes Bmp signaling to orchestrate cardiac morphogenesis in space and time

Joshua Theisen:

38-FOXF1 opens chromatin to mediate Hedgehog-dependent heterochronic regulation of cardiac progenitor differentiation

Kelly Twohig:

39-Trends in left ventricular myocardial volume before and after TEVAR

Ullah Karim:

40-Plasmalemma Vesicle-Associated Protein (PLVAP) regulates Cardiac Endothelial Permeability is ARNT dependent

Markus Rottmann:

41-Exploring the Interplay of Functional and Structural Remodeling Progression in Atrial Fibrillation in a Rapid Atrial Pacing Canine Model
42-Dominant Clockwise and Anti-Clockwise Rotation Direction of Multiple Interacting Rotational Activities in the Fibrillating Atrium
43-Targeted Ablation at Regions of High Oxidative Injury in Persistent Atrial Fibrillation in a Canine Model
44-Uncovering Regions of High Oxidative Injury in Persistent Atrial Fibrillation Patients and in a Canine Model
45-Reactive Oxygen Species Scavenging Reduces Complex Fractionated Atrial Electrograms (CFAEs) In Persistent Atrial Fibrillation Patients

Yael Wollstein:

46-Sex-specific remodeling in light-chain cardiac amyloidosis assessed by cardiac magnetic resonance informs prognosis
47-Invasive Hemodynamic Validation of the Novel HFpEF-JH Risk Score
48-Early Post-Operative Significant Liver Dysfunction in Patients Undergoing Heart Transplant

Ryan Ran Yang:

49-Left Atrial Reservoir Strain as a Surrogate for Elevated Left Ventricular End Diastolic Pressure Across the Ejection Fraction Spectrum

Shin Yoo:

50-Disruption of microtubule network is dependent on frequency-dependent and NOX2-generated-ROS in canine atrial myocytes

Leroy Bondhus:

51-Evolution of genetic architectures encoding pleiotropic gene expression in cardiac and mesodermal regulatory programs across Metazoa

Honorable Distinction Abstracts:

Electrical Properties and Regulatory Mechanisms of Arrhythmic Substrate in Aging - Bartu Altiparmak

Birth defect causation in Down Syndrome: Diminished response to Hedgehog signaling in Trisomy 21 cardiac progenitors - Shalise Burch

Therapeutic potential of caloric restriction-induced macrophages (CR-Mø) for atherosclerosis resolution - Lourdes Caceras

Noninvasive Assessment of Left Ventricular Performance Using Pressure-Volume Loops Derived from Three-Dimensional Echocardiography - Martin Gruca

Comparative genomics between human and chimpanzees –using cardiovascular cell types as an example - Hsin-Chiao Huang

Differential Temporal Dynamics of Parasympathetic and Sympathetic Cardiac Nerve Activity and Electrogram Patterns in a Chronic Atrial Fibrillation Canine Model - Aleksei Mikhailov

Advanced Right-Sided Hemodynamic Parameters for Prognostication in Patients with Cardiogenic Shock - Joanna Obaoye

Region-Specific Frequency Dependent Upregulation of Senescence Markers in the Left Atrium in a Chronic Atrial Fibrillation Canine Model - Cian O’Donnell

Echocardiographic Phenotypes of Severe Pulmonary Arterial Hypertension Defined by Unsupervised Machine Learning Informs Prognosis - Michael Randazzo

FOXF1 opens chromatin to mediate Hedgehog-dependent heterochronic regulation of cardiac progenitor differentiation - Joshua W. M. Theisen

Left Atrial Reservoir Strain as a Surrogate for Elevated Left Ventricular End Diastolic Pressure Across the Ejection Fraction Spectrum - Ryan Ran Yang

5:00 – 5:30 PM — Featured Poster Presentations

Sodium Glucose CoTransporter-2 Inhibitor following Left Ventricular Assist Device Implantation: a Randomized Controlled Trial - Mary Acosta

Left Bundle Branch Block with Time to Notch in Lead I is a Predictor of Response to Cardiac Resynchronization Therapy: A Sub-Analysis of the REVERSE Study - Matthew Padanilam

Targeted Ablation at Regions of High Oxidative Injury in Persistent Atrial Fibrillation in a Canine Model - Markus Rottmann

Friday, May 9, 2025

W632

12:00 to 1:00 PM — Keynote Speaker

Emerging Therapies in Hypertrophic Cardiomyopathy

Theodore Abraham, MD

Dr. Theodore Abraham is the Meyer Friedman Distinguished Professor of Medicine and Clinical Chief of Cardiology at University of California at San Francisco. Previously, he was Associate Dean for Community Research at Johns Hopkins Medicine, and Professor of Medicine and Radiology, and Radiologic Sciences at Johns Hopkins University. He is a board-certified cardiologist with expertise in Hypertrophic Cardiomyopathy and co-founded the Johns Hopkins and UCSF HCM Centers of Excellence. He has over 200 peer-reviewed publications with 20+ years of NIH funding. He has been involved in several HCM clinical trials including EXPLORER, REDWOOD, SEQUOIA, ODYSSEY, ACACIA, CIRRUS, MyPeak-1 and IMPROVE, among others. He founded and served as the first President of the Hypertrophic Cardiomyopathy Medical Society (HCMS) and is currently President of the American Society of Echocardiography.

Morton F. Arnsdorf, MD

Morton F. Arnsdorf, M.D., M.A.C.C. was a Professor of Medicine at the University of Chicago and was Chief of the Section of Cardiology for 9 years (1981 to 1990). He also served as Associate Vice-Chairman for Appointments and Promotions in the Department of Medicine. This was a position of honor for Dr. Arnsdorf, who loved to cultivate junior faculty careers.

Dr. Arnsdorf received his B.A. from Harvard College and his M.D. from the College of Physicians and Surgeons of Columbia University. He received his residency training at the University of Chicago, his cardiology training at the Columbia-Presbyterian Hospital in New York, and served in the United States Air Force before returning to the University of Chicago as a member of the Faculty in 1973.

Dr. Arnsdorf had an active clinical practice and routinely attended on the inpatient housestaff services at the University of Chicago Hospitals. Dr. Arnsdorf made many scientific contributions to cardiovascular cellular physiology by investigating how abnormal heart rhythms arise and how antiarrhythmic drugs work. He pioneered biological applications of atomic force microscopy. Dr. Arnsdorf was also an active clinician scientist, and in the last decade of his life, his clinical interest focused on heart disease in women. In 2006, the American Heart Associated presented him the Mentoring of Women in Cardiology Award. He was also involved in developing computerized education for students and physicians.

Dr. Arnsdorf was a leader and mentor. He was also quite familiar with the business of medicine as a result of being the Chief of Cardiology at the University of Chicago during a time when medicine in America was changing rapidly. He relished policy-making roles in health research as a member of several study sections and advisory panels of the National Institutes of Health and other governmental organizations, and with a number of professional organizations. He became Vice-Chairman of the Department of Medicine in 2004 and was elected to the Committee of the Council of the University of Chicago in 2006. He was a Secretary and Trustee of the American College of Cardiology (ACC) and served as Chair of both the Constitution and Bylaws Committee and the Awards Committee. He was conferred the honor of Master of the ACC and was given the Distinguished Fellow Award in 2005. He was Governor of the Illinois chapter of ACC and a member of the Board of Trustees of the national ACC. He was a member of the ACC Task Force on Health Care Quality Improvement and served as liaison to Blue Cross/Blue Shield. He was a member of the Board of Governors and the Chairman of the Basic Science Council of the American Heart Association (AHA), President of the American Heart Association of Metropolitan Chicago, President of the Cardiac Electrophysiology Society, a founding member of the Association of Professors of Cardiology, a member of the nominating committee of the Association of University Cardiologists, and Secretary-Treasurer of the Central Society for Clinical Research. Dr. Arnsdorf was the Associate Clinical Coordinator for the Illinois Cooperative Cardiovascular Project, focused on health care quality initiatives in patients with myocardial infarction. He served on a number of major University Committees.

Dr. Arnsdorf’s interests were broad in both the arts and sciences. As a result of his interests and activities in biomedical ethics, he was asked to be a member of the Interdisciplinary Panel on Medical, Legal, and Ethical Issues Surrounding Decisions on Life Support Treatments of the Illinois State Bar Association in 1986 which was charged with suggesting legislation. He came to this through his practice of cardiology and through involvement with a hospice in a medically underserved area of Chicago's south side. His wife, Rosemary Crowley, was the past Executive Director of the Illinois State Hospice Organization. He had been working on a project on the design and availability of advance directives until his death in 2010.

Dr. Arnsdorf was a prolific writer throughout his life and often typed on a keyboard as if he were playing a piano. He authored hundreds of original papers, abstracts and book chapters. He was an Associate editor of Circulation Research and a member of the editorial board of Circulation, Circulation Research, the Journal of the American College of Cardiology, the Journal of Cardiovascular Pharmacology, and the Journal of Laboratory and Clinical Medicine. He was also a reviewer for virtually all the major basic science and clinical journals in cardiovascular disease. He was a co-editor of the cardiovascular section of Up-To-Date.

Morton F. Arnsdorf, M.D., MACC was more than a great doctor and scientist. He was a great human being and embodied too many qualities to be included in this space. It was his unending friendship to us all and his love of the University of Chicago, Section of Cardiology that links his name to this Cardiovascular Research Day. Please enjoy the scientific interaction with our colleagues today as Mort undoubtedly would have.

Organized by the Section of Cardiology

Rishi Arora, MD: Professor of Medicine; Chief, Section of Cardiology

Planning Committee

Francis Alenghat, MD, PhD: Associate Professor of Medicine, Section of Cardiology
Jonathan Grinstein, MD: Associate Professor of Medicine, Section of Cardiology
Amber Johnson, MD: Assistant Professor of Medicine, Section of Cardiology
Victor Mor-Avi, PhD: Professor; Director of Cardiac Imaging Research, Section of Cardiology
Cevher Ozcan, MD, PhD: Associate Professor of Medicine, Section of Cardiology
Jeremy Slivnick, MD: Assistant Professor of Medicine, Section of Cardiology
J. Andrew Wasserstrom, PhD: Director of Basic Research, Section of Cardiology
Charisse Hopkins: Administrative Specialist, Section of Cardiology
Melissa Meskers: Administrative Manager, Section of Cardiology

Special thanks to additional Abstract Judges Matthew Sorrentino, MD and Rongxue Wu, MD, PhD

Special thanks to our 2025 participating exhibitors: Janssen, Pfizer, Novartis